Asymptotic Inference with Response-Adaptive Treatment Allocation Designs
نویسندگان
چکیده
منابع مشابه
Asymptotic Properties of Covariate - Adjusted Response - Adaptive Designs
Response-adaptive designs have been extensively studied and used in clinical trials. However, there is a lack of a comprehensive study of responseadaptive designs that include covariates, despite their importance in clinical trials. Because the allocation scheme and the estimation of parameters are affected by both the responses and the covariates, covariate-adjusted responseadaptive (CARA) des...
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The play-the-winner (PW) rule is an important method in clinical trials where patients can be assigned to one of the two treatments. In the PW rule, the probability of the next patient to be assigned to a particular treatment only depends on the response of the current patient. In this paper, we consider a general kind of PW rule for multi-treatment adaptive designs, in which the probability th...
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Owing to the benefits that higher proportions of patients are likely to receive the better treatment, response-adaptive designs are considered to be valuable statistical tools in clinical studies. Nevertheless, there is a lack of a comprehensive study of adaptive designs with the inclusion of covariates, regardless of their importance in clinical experiments. The major reason is that covariatea...
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Methods for controlling the type-1 error of an adaptive group sequential trial were developed in seminal papers by Cui, Hung, and Wang (Biometrics, 1999), Lehmacher and Wassmer (Biometrics, 1999), and Müller and Schäfer (Biometrics, 2001). However, corresponding solutions for the equally important and related problem of parameter estimation at the end of the adaptive trial have not been complet...
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We provide adaptive designs for the sequential allocation of treatments to patients in a clinical trial when the responses are approximately normally distributed. The skewing of the allocations towards the better treatments depends on target proportions for the ranked treatment effects. In addition we combine balance across prognostic factors with a controllable amount of randomization. The asy...
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ژورنال
عنوان ژورنال: The Annals of Statistics
سال: 1993
ISSN: 0090-5364
DOI: 10.1214/aos/1176349412